This comprehensive textbook communicates the complexities of abnormal psychology, speaks to the concerns of students, and empathically portrays the real human impact of psychological disorders. For the ninth edition, award-winning teacher Ronald Comer is joined by Jonathan Comer, who brings his expertise in developmental psychopathology research, brain circuitry, cognitive-behavioural research, and technology-driven treatment. With its signature integrated coverage of theory, diagnosis, and treatment, and inclusive cross-cultural perspective, this new edition is an engaging introduction to where the study and treatment of psychological disorders stands today.
Six feature-length action adventures based on the Marvel comic strip. In 'X-Men' (2000), mutants Professor Charles Xavier (Patrick Stewart) and Magneto (Ian McKellen) are former friends, but look set to become mortal enemies when a fascist US senator calls for the registration of all humans with abnormal powers. While telepath Xavier, who runs an altruistic academy for superhuman 'X-Men', wishes to enlighten non-mutants and break down the prejudices which divide them, Magneto believes that the only solution is for the mutants to take over. Wolverine (Hugh Jackman) - an aggressive loner with an adamantium skeleton and the ability to heal his body of any wound - and teenager Rogue (Anna Paquin), who can absorb the life force of others simply by touching them, are selected by Xavier to join his academy, but it isn't long before Magneto's followers are attempting to capture them so that they can assist in his plan for world domination. In the sequel, 'X-Men 2' (2003), Xavier, Wolverine and the X-Men find themselves in the firing line after a failed assassination attempt on the president points the finger at the school. It was in fact the mysterious teleporter Nightwalker (Alan Cumming) who ordered it, and, in an attempt to clear their names, the X-Men are led into a trap set by the evil William Stryker (Brian Cox), a mysterious scientist apparently working for the government. In the third film, 'X-Men: The Last Stand' (2006), the mutants are given the option of giving up their powers and becoming human after a private laboratory supported by the government finds a way to use the DNA of a powerful boy to correct the mutants. However, Magneto opposes and decides to join a force to fight against the government and kill the mutant boy. Meanwhile, Jean Grey (Famke Janssen) resurrects, uncontrolled by Xavier, and with the personality of the powerful Dark Phoenix. She destroys Cyclops (James Marsden) and Xavier and allies herself to the evil forces of Magneto, making them almost invincible. The fourth film in the franchise, 'X-Men: Origins - Wolverine' (2009), is a prequel to the other three films. Jackman reprises his role as Wolverine, who, some 20 years before the action of the original movie, is seeking revenge on his half-brother Victor Creed (Liev Schreiber) for the death of his girlfriend, and eventually signs up to the ominous Weapon X programme. 'X-Men: First Class' (2011) charts the beginning of the saga, following Professor X (James McAvoy) and Magneto (Michael Fassbender) through their formative years in the 1960s as they come to terms with their newfound superpowers. Initially close friends who work together to fight against evil, the two men are driven apart by a conflict of opinion that ultimately leads to the eternal war between Magneto's Brotherhood and Professor X's X-Men. Finally, 'The Wolverine' (2013) finds the eponymous hero vulnerable, alone and at his lowest point after the events of 'X-Men: The Last Stand'. Drawn to modern-day Japan by the gratitude of a wealthy industrialist from his past who secretly covets his healing powers, Logan aka Wolverine soon finds himself up against the deadly charms of a femme fatale known as 'The Viper' (Svetlana Khodchenkova), whilst having to confront samurai steel and lethal ninjas as his destiny draws him towards a winner-takes-all battle with his ultimate foe 'The Silver Samurai' (Will Yun Lee).
Research Paper (undergraduate) from the year 2008 in the subject Business economics - Investment and Finance, grade: 1.7, The FOM University of Applied Sciences, Hamburg, language: English, abstract: Especially after the 90ies, where the stock markets raised enormously, many private investors joined the stock market and were blended by abnormal profits and neglected possible losses. The same behavior could be observed before the Financial Crisis became reality. But each endless raising stock market would finally collapse, because stock prices are randomly and only driven by relevant news. The adjustment to the news is quickly. This is the theoretical argumentation of the Efficient Market Hypothesis (EMH), which will be evaluated in this paper.The author gives an overview about the EMH by explaining the basic principles and its mathematical formulation. The practical part evaluated the EMH on selected examples, where the theory could only be partly approved.
Here we present evidence that the transcription factor Teashirt (Tsh) has a role in cell proliferation in Drosophila follicle stem cells (FSC), neuroblasts and S2 cells. In ovaries, Tsh and Hedgehog (Hh) are co-expressed in the terminal filament and cap cells. The characterisation of a new tsh mutation causing female sterility allowed us to show that Tsh acts via Hh-mediated signalling pathway to control FSC proliferation. In this tsh background, the hsGal4 driven expression of tsh or hh partially rescues the abnormal phenotype allowing oogenesis progression. Furthermore, tsh overexpression mimics the hh overexpression associated phenotype. In neuroblasts, mutant tsh alleles are unable to exit mitosis. The phenotypes of double mutants with rod or bub1 resemble the tsh single mutant phenotype, suggesting failure to escape mitosis. Finally, tsh depletion in S2 cells mimics the tsh mutant phenotype in neuroblasts. We propose that during oogenesis, tsh affects FSC proliferation mediating Hh expression. In neuroblasts, tsh may also acts through Hh signalling, since expression of interference hedgehog, was severely downregulated in our DNA microarray analysis.
Previous studies, in most cases, investigated share repurchases for undervalued companies. This work is dedicated to a deeper analysis of the reasons for share buybacks of the most prominent US firms, which are not likely to be undervalued. Hence, empirical evidence shows that the sample firms tend to repurchase more shares if there are no good investment possibilities available or as a vehicle for eliminating shares dilution when the stock options are exercised. Investigating 308 announcements of 100 companies ever included into the S&P100 index between 2005 and 2014, I observed positive and significant short-term cumulative abnormal returns after the companies had published information about the share repurchase program authorization in all years except 2009. In order to show how valuable announcements about planned share repurchases might be for market participants, eight event-driven investment strategies are constructed and evaluated in this work.
Hepatotoxicity (from hepatic toxicity) implies chemical-driven liver damage. The liver plays a central role in transforming and clearing chemicals and is susceptible to the toxicity from these agents. Certain medicinal agents when taken in overdoses and sometimes even when introduced within therapeutic ranges may injure the organ. Other chemical agents such as those used in laboratories and industries, natural chemicals (e.g. microcystins) and herbal remedies can also induce hepatotoxicity. Chemicals that cause liver injury are called hepatotoxins. More than 900 drugs have been implicated in causing liver injury and it is the most common reason for a drug to be withdrawn from the market. Chemicals often cause subclinical injury to liver which manifests only as abnormal liver enzyme tests. Drug induced liver injury is responsible for 5% of all hospital admissions and 50% of all acute liver failures.
Due to advances in information science and technology in the last decades, we are passing through an era of information explosion and globalization, which has led to the problem of information overloading. At the same time, researches in different area are maturing and a race for knowledge has begun in which boundaries between different disciplines have narrowed. These days interdisciplinary research is very common and involves two fields embedded together to deal with the complexity and sheer quantum of information. This book examines different data-driven techniques for utilization of available data to infer useful information about the state of the systems and processes. Several novel techniques such as Radial Basis based Nonlinear Feature Extraction, Modular Fuzzy Net and Self-Organizing Self-Clustering Network are proposed in this book. These techniques are amalgamation of several existing techniques and utilize their important features to facilitate proactive identification, detection and diagnosis of any abnormal situations.
Control systems at production plants consist of a large number of process variables. When detecting abnormal behavior, these variables generate an alarm. Due to the interconnection of the plant's devices the fault can lead to an alarm flood. This again hides the original location of the causing device. In this work several data-driven approaches for root cause localization are proposed, compared and combined. All methods analyze disturbed process data for backtracking the propagation path.
Allergic contact dermatitis (ACD) arises from a delayed type IV hypersensitivity response and is one of the most common skin diseases, affecting 15-20% of the general population worldwide. Although the pharmacological agents cortisol, prednisolone, and dexamethasone are used for the treatment of allergies, inflammation, and autoimmune disorders, the side effects of these drugs have driven attempts to develop more effective immune modulating agents. Although the consumption of natural foods has been linked to the prevention or alleviation of abnormal immune responses to foreign pathogens and products, including hapten compounds, from a functional food perspective, evidence for the preventive effects of natural compounds against ACD is necessary before such materials can be used in pharmaceutical preparations.