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Abnormal Embryogenesis
92,99 € *
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Abnormal Embryogenesis ab 92.99 € als Taschenbuch: Cellular and Molecular Aspects. Softcover reprint of the original 1st ed. 1979. Aus dem Bereich: Bücher, Wissenschaft, Biologie,

Anbieter: hugendubel
Stand: 01.04.2020
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Abnormal Embryogenesis
92,99 € *
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Abnormal Embryogenesis ab 92.99 EURO Cellular and Molecular Aspects. Softcover reprint of the original 1st ed. 1979

Anbieter: ebook.de
Stand: 01.04.2020
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UBE1C
45,00 € *
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Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. NEDD8-activating enzyme E1 catalytic subunit is a protein that in humans is encoded by the UBA3 gene. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme associates with AppBp1, an amyloid beta precursor protein binding protein, to form a heterodimer, and then the enzyme complex activates NEDD8, a ubiquitin-like protein, which regulates cell division, signaling and embryogenesis.

Anbieter: Dodax
Stand: 01.04.2020
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Abnormal Embryogenesis
168,00 CHF *
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The study of birth defects has assumed an importance even greater now than in the past because mortality rates attributed to congenital anomalies have declined far less than those for other causes of death, such as infectious and nutritional diseases. It is estimated that as many as 50% of all pregnancies terminate as miscarriages. In the majority of cases this is the result of faulty development. Major congenital malformations are found in at least 2% of all liveborn infants, and 22% of all stillbirths and infant deaths are associated with severe congenital anomalies. Teratological studies of an experimental nature are neither ethical nor justifiable in humans. Numerous investigations have been carried out in laboratory animals and other experimental models in order to improve our understanding of abnormal intrauterine development. In less than two decades the field of experimental teratology has advanced phenomenally. As a result of the wide range of information that is now accumulating, it has become possible to obtain an insight into the causes, mechanisms, and prevention of birth defects. However, considerable work will be needed before these problems can be resolved. The comributions in this volume include some of the more recent and exciting observations on the cellular and molecular aspects of developmental defects. It is not only a documentation of the latest experimental work, but it also indicates new and important areas for future research.

Anbieter: Orell Fuessli CH
Stand: 01.04.2020
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Reelin Glycoprotein
257,90 CHF *
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Reelin glycoprotein is a serine protease with important roles in embryogenesis and during adult life. Reelin mutations or deficiency of the protein product could cause abnormal cortical development and reelin signaling impairment in brain. Reelin abnormalities in several neurospychiatric disorders, such as autism, schizophrenia, mood disorders and lissencephaly, may provide mechanistic explanations for etiologies of these disorders. There is also emerging data indicating the feasibility of using various medications (valproic acid, olanzapine) to increase mRNA/protein levels for reelin and/or gene therapy to prevent or treat reelin deficiencies observed in the above-mentioned disorders. This comprehensive and integrative book examines the role that reelin plays in the etiology of various neuropsychiatric disorders, including schizophrenia and autism. TOC:The Reelin Gene and Its Functions in Brain Development.- Apolipoprotein E Receptor 2 and Very Low Density Lipoprotein Receptor: An Overview.- Chemistry of Reelin.- The C-terminal region of Reelin: structure and function.- Crystal Structure of Reelin Repeats.- Comparative Anatomy and Evolutionary Roles of Reelin.- Reelin / Dab1 Signaling in the Developing Cerebral Cortex.- Ultrastructural Localization of Reelin.- Reelin and Cyclin-Dependent Kinase 5.- Reelin and the Cerebellum.- Reelin and Radial Glial Cells.- Reelin and Cognition.- Protein Kinases and Signaling Pathways that are Activated by Reelin.- The Relationship of Oxytocin and Reelin in the Brain.- Reelin and Thyroid Hormone.- A Tale of Two Genes: Reelin and BDNF.- Reelin, Liver, and Lymphatics.- Reelin and Cajal-Retzius Cells.- Reelin and Odontogenesis.- Homozygous and Heterozygous Reeler Mouse Mutants.- Reelin and Lissencephaly.- The Role of Reelin in Etiology and Treatment of Psychiatric Disorders.- Reelin Downregulation as a Prospective Treatment Target for GABAergic Dysfunction in Schizophrenia.- Epigenetic Modulation of Reelin Function in Schizophrenia and Bipolar Disorder.- Reelin Gene Polymorphisms in Autistic Disorder.- Alzheimer's and Reelin.- Reelin and Stroke.- Reelin and Pancreatic Cancer.

Anbieter: Orell Fuessli CH
Stand: 01.04.2020
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Abnormal Embryogenesis
89,99 € *
ggf. zzgl. Versand

The study of birth defects has assumed an importance even greater now than in the past because mortality rates attributed to congenital anomalies have declined far less than those for other causes of death, such as infectious and nutritional diseases. It is estimated that as many as 50% of all pregnancies terminate as miscarriages. In the majority of cases this is the result of faulty development. Major congenital malformations are found in at least 2% of all liveborn infants, and 22% of all stillbirths and infant deaths are associated with severe congenital anomalies. Teratological studies of an experimental nature are neither ethical nor justifiable in humans. Numerous investigations have been carried out in laboratory animals and other experimental models in order to improve our understanding of abnormal intrauterine development. In less than two decades the field of experimental teratology has advanced phenomenally. As a result of the wide range of information that is now accumulating, it has become possible to obtain an insight into the causes, mechanisms, and prevention of birth defects. However, considerable work will be needed before these problems can be resolved. The comributions in this volume include some of the more recent and exciting observations on the cellular and molecular aspects of developmental defects. It is not only a documentation of the latest experimental work, but it also indicates new and important areas for future research.

Anbieter: Thalia AT
Stand: 01.04.2020
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Motion Analysis of Living Cells
489,99 € *
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Most active cellular functions involve motion. From such subtle subcellular actions as the sorting and targeting of vesicles and organelles leading to the release of hormones to the complex rearrangements of a sphere of embryonic cells forming the body plan of a complete organism, motility of cells is exhibited along a wide range of observable behaviors. Despite this phenomenon, however, the views of modern biology historically have been based on static images and models constructed from biochemical evidence. Motion Analysis of Living Cells is the first volume to compile the latest research by prominent specialists in molecular and cell biology, presenting newly developed techniques for studying cellular motions and critical analyses of the information these techniques can yield. Focusing on actin-based motility systems and drawing on the latest advances in the techniques of biochemistry, biophysics, microscopy, computer-assisted motion analysis, and molecular genetics, the works in this collection will prove invaluable to future research in embryogenesis, cancer, and diseases related to the cellular immune system. Among the topics covered: * Bacterial motility and chemotaxis * New technologies for characterizing motility-related parameters * Methods for analyzing the cortical tension of normal cells compared to abnormal cells * Model for how a cell extends a pseudopod * Computer-assisted analyses of cytoskeletal mutants of Dictyostelium discoideum * Emerging methods for studying how cells respond to topographical cues at the substratum * Polymerization of host actin to facilitate propulsion * Genetic approaches to the regulatory mechanisms involved in early zebra fish morphogenesis and specification of cell fates * Specific examples of single cell motility in embryogenesis * Research oriented toward understanding cancer cell arrest, extravasation, and migration A groundbreaking treatment of motion analysis of animal cells, Motion Analysis of Living Cells is a thorough review for professionals as well as a comprehensive introduction for students and researchers in the field. It is must reading for cell and developmental biologists, microbiologists, immunologists, neuroscientists, cancer researchers, zoologists, and basic researchers in reproductive medicine.

Anbieter: Thalia AT
Stand: 01.04.2020
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Reelin Glycoprotein
218,90 € *
ggf. zzgl. Versand

Reelin glycoprotein is a serine protease with important roles in embryogenesis and during adult life. Reelin mutations or deficiency of the protein product could cause abnormal cortical development and reelin signaling impairment in brain. Reelin abnormalities in several neurospychiatric disorders, such as autism, schizophrenia, mood disorders and lissencephaly, may provide mechanistic explanations for etiologies of these disorders. There is also emerging data indicating the feasibility of using various medications (valproic acid, olanzapine) to increase mRNA/protein levels for reelin and/or gene therapy to prevent or treat reelin deficiencies observed in the above-mentioned disorders. This comprehensive and integrative book examines the role that reelin plays in the etiology of various neuropsychiatric disorders, including schizophrenia and autism. TOC:The Reelin Gene and Its Functions in Brain Development.- Apolipoprotein E Receptor 2 and Very Low Density Lipoprotein Receptor: An Overview.- Chemistry of Reelin.- The C-terminal region of Reelin: structure and function.- Crystal Structure of Reelin Repeats.- Comparative Anatomy and Evolutionary Roles of Reelin.- Reelin / Dab1 Signaling in the Developing Cerebral Cortex.- Ultrastructural Localization of Reelin.- Reelin and Cyclin-Dependent Kinase 5.- Reelin and the Cerebellum.- Reelin and Radial Glial Cells.- Reelin and Cognition.- Protein Kinases and Signaling Pathways that are Activated by Reelin.- The Relationship of Oxytocin and Reelin in the Brain.- Reelin and Thyroid Hormone.- A Tale of Two Genes: Reelin and BDNF.- Reelin, Liver, and Lymphatics.- Reelin and Cajal-Retzius Cells.- Reelin and Odontogenesis.- Homozygous and Heterozygous Reeler Mouse Mutants.- Reelin and Lissencephaly.- The Role of Reelin in Etiology and Treatment of Psychiatric Disorders.- Reelin Downregulation as a Prospective Treatment Target for GABAergic Dysfunction in Schizophrenia.- Epigenetic Modulation of Reelin Function in Schizophrenia and Bipolar Disorder.- Reelin Gene Polymorphisms in Autistic Disorder.- Alzheimer's and Reelin.- Reelin and Stroke.- Reelin and Pancreatic Cancer.

Anbieter: Thalia AT
Stand: 01.04.2020
Zum Angebot