Analysis of Placental Gene Expression Profile in Abnormal Fetal Growth ab 51.99 € als Taschenbuch: . Aus dem Bereich: Bücher, Wissenschaft, Biologie,
Acute leukemia is a type of blood cancer. It starts when your bone marrow produces abnormal white blood cells. These aberrant cells are then spread into your blood, causing suppression of normal blood elements. In this book we study cases of childhood acute lymphoblastic leukemia, assessing the expression of the interleukin 3 receptor Alpha subunit (CD123) by flow cytometric analysis and other parameters trying to find links of haematopathology finding with out come and the prognosis of such children. Hope you will get beneficial scientific informations
Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. Ubiquitin-conjugating enzyme E2 G2 is a protein that in humans is encoded by the UBE2G2 gene. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein shares 100% sequence identity with the mouse counterpart. This gene is ubiquitously expressed, with high expression seen in adult muscle. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. Ube2g2 is known to interact with a variety of other proteins, including but not limited to ubiquitin, the E3 gp78, and the Hrd1 RING.
Sickle cell disease is best known as an inherited hemolytic disorder of defective hemoglobin that distorts red blood cell morphology, function and lifespan. It is less well known as a disease that targets the microvasculature, characterized by increased expression of cell adhesion molecules, enhanced production of reactive oxygen species, abnormal blood cell-endothelial cell interactions in postcapillary venules and altered vasomotor responses in arterioles. These microvascular responses are crucial to the initiation and progression of vasoocclusive crises, the disease s critical pathophysiological event that leads to pain crises, organ injury and early mortality. This work considers sickle cell disease vascular pathology in terms of the cellular, molecular and biochemical players that participate in the evolution,progression and resolution of vasoocclusive crises. The work provides a comprehensive overview of the complex pathophysiology of sickle cell disease and is an ideal reference source for professionals in the medical and scientific community.
It was hypothesized that diabetic alterations in the expression of insulin-like growth factors (IGFs) and their receptors may create an abnormal intrauterine environment thus affect early embryo development. This book, therefore, presents studies that were conducted to determine the effects of diabetes on in vitro development of mouse preimplantation embryos as well as mRNA and protein expression of IGF-1, IGF-2, IGF-1R and IGF-2R in the fallopian tube and uterine tissue. The findings showed that the percentage of the two-cell stage embryos which developed to blastocysts was similar in control and diabetic groups but whether the quality of these embryos were the same remains to be investigated. Both the mRNA and protein expression of IGFs and their receptors were significantly altered by maternal diabetes, which suggest the role of IGFs in the pathogenesis of diabetic embryopathy. This book is a good reference for students and professionals doing research in early embryo development.
The goal of this book is to provide a more effective way to extract features with highly important information to a specific disease, i.e. informative features, using correlation based rough set feature extraction method (RSs), rough set, genetic algorithms (GAs) and its variants, fuzzy-rough set, nearest neighbor, decision tree algorithms and partial least square method and some adaptive neural networks due to their learning abilities to construct hypotheses that can explain complex relationships in the data. This research explores the effectiveness of integrated and hybrid feature extraction methods proposed in the following chapters, in analyzing gene expression activities, based on a specific tumor disease and identifying the informative genes that underlie different precision levels in the extraction process. The identified gene subset may give an enhanced insight on the gene-gene interaction in response to different stages of abnormal cell growth which could be vital in designing treatment strategies to prevent any progression of abnormal cells.
Radiation of its different types is one of the major well known mutagenesis factors. Man exposes to different types of radiation which is used in diagnosis of diseases or treatment and the exposure through work or environmental is the other factor to mutagenesis. Low dose of ionizing radiation induces DNA damage on normal cells and abnormal cells. Healthy individuals show normal functions of genes manifested as normal gene expression of the very well-known DNA repair genes are the XRCC1, XRCC2 and FOXM1 regulator genes. In this work, other biomarkers for DNA damage were investigated, like level of 8-ohdG in urine samples, comet assay also performed in same samples and total of antioxidant capacity (TAC) was measured in serum.
Epigenetic is heritable changes in gene expression that do not involve changes in DNA sequence,is known to be involved in disease. Two important epigenetic changes that are known to contribute to disease are abnormal methylation patterns of DNA and modifications of histones in chromatin.This therapy describes a new development in pharmacology,epigenetic therapy,which attempts to correct these changes.
This work focuses on the identification of specific structural properties of cypin that lead to the multifunctional roles in guanine metabolism and dendrite development. We first employed phylogenetic analysis and computational structure modeling techniques to construct a three dimensional structural model of cypin. In addition, we used a combination of protein structure analysis, experimental kinetic studies, and cell culture tests to uncover novel potential ligands for cypin. We obtained a list of compounds that demonstrate higher binding affinity to GDA than does guanine. Our results provide evidence that an in silico drug discovery strategy coupled with in vitro verification can be successfully implemented to discover compounds that may have therapeutic value for the treatment of diseases and disorders where GDA activity is abnormal. The discovery of intrinsic regulators of cypin expression aids in our understanding of molecular mechanisms underlying dendritic patterning, and hence, synaptic plasticity, learning and memory.