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Analysis of Placental Gene Expression Profile i...
53,40 € *
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Molecular biology of the placenta is a fascinating research subject to investigate the mechanisms underlying fetal growth abnormalities and developmental disorders. Analysis of Placental Gene Expression Profile in Abnormal Fetal Growth provides a new insight into the gene dysregulation and pathway changes in the placenta of pregnancies affected by fetal growth restriction and macrosomia. This book reviews the physiology of the placenta and its divers roles in maintaining a healthy fetal development. There is a summary of the aetiology of abnormal fetal growth and its adverse effects on the future of infants. The main focus of this book is presenting the findings achieved by microarray gene expression analysis in the placentas collected from growth restricted and macrosomic newborns, introducing some candidate genes for screening purposes. In addition, molecular function of dysregulated genes and affected biological pathways have been described in detail.

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Stand: 17.01.2020
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Chromosomal Instability in Cancer Cells
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This issue of Recent Results in Cancer Research presents a comprehensive review of current understanding of chromosomal instability in cancer and of strategies to use this information for better treatment of patients with cancer. Cancer is a disease of the chromosomes, and chromosomal instability in cancer disrupts gene function by either inactivating tumor suppressor genes or activating growth-promoting oncogenes. The chromosomal basis for these aberrations is either translocations, which change the integrity of genes, or abnormal numbers of chromosomes, a condition referred to as aneuploidy, which results in abnormal gene expression levels. Such structural or numerical chromosomal aberrations are specific for distinct tumor entities. The degree of chromosomal instability and the degree of intratumor heterogeneity have profound consequences for disease outcome and for therapeutic stratification.

Anbieter: Dodax AT
Stand: 17.01.2020
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Chromosomal Instability in Cancer Cells
79,98 € *
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This issue of Recent Results in Cancer Research presents a comprehensive review of current understanding of chromosomal instability in cancer and of strategies to use this information for better treatment of patients with cancer. Cancer is a disease of the chromosomes, and chromosomal instability in cancer disrupts gene function by either inactivating tumor suppressor genes or activating growth-promoting oncogenes. The chromosomal basis for these aberrations is either translocations, which change the integrity of genes, or abnormal numbers of chromosomes, a condition referred to as aneuploidy, which results in abnormal gene expression levels. Such structural or numerical chromosomal aberrations are specific for distinct tumor entities. The degree of chromosomal instability and the degree of intratumor heterogeneity have profound consequences for disease outcome and for therapeutic stratification.

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UBE2I
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Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. SUMO-conjugating enzyme UBC9 is a protein that in humans is encoded by the UBE2I gene. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Four alternatively spliced transcript variants encoding the same protein have been found for this gene.

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Stand: 17.01.2020
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UBE2E1
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Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. Ubiquitin-conjugating enzyme E2 E1 is a protein that in humans is encoded by the UBE2E1 gene. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

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UBE2L6
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Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. Ubiquitin/ISG15-conjugating enzyme E2 L6 is a protein that in humans is encoded by the UBE2L6 gene. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is highly similar in primary structure to the enzyme encoded by UBE2L3 gene. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

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UBE2A
46,30 € *
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Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. Ubiquitin-conjugating enzyme E2 A is a protein that in humans is encoded by the UBE2A gene. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair. Multiple alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms.

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UBIAD1
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Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. UbiA prenyltransferase domain-containing protein 1 is an enzyme that in humans is encoded by the UBIAD1 gene. Mutations of the gene cause Schnyder crystalline corneal dystrophy. Schnyder crystalline corneal dystrophy (SCD) is a rare form of human corneal dystrophy. It is caused by heterozygous mutations in UBIAD1 gene. Cells in the cornea accumulate cholesterol and phosopholipid deposits leading to the opacity, in severe cases requiring corneal transplants. Abnormal cholesterol metabolism has been noted in other cell types of affected patients (skin fibroblasts) suggesting that this may be a systemic disorder with clinical manifestations limited to the cornea.

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Knowledge Discovery using Machine Learning Algo...
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The goal of this book is to provide a more effective way to extract features with highly important information to a specific disease, i.e. informative features, using correlation based rough set feature extraction method (RSs), rough set, genetic algorithms (GAs) and its variants, fuzzy-rough set, nearest neighbor, decision tree algorithms and partial least square method and some adaptive neural networks due to their learning abilities to construct hypotheses that can explain complex relationships in the data. This research explores the effectiveness of integrated and hybrid feature extraction methods proposed in the following chapters, in analyzing gene expression activities, based on a specific tumor disease and identifying the informative genes that underlie different precision levels in the extraction process. The identified gene subset may give an enhanced insight on the gene-gene interaction in response to different stages of abnormal cell growth which could be vital in designing treatment strategies to prevent any progression of abnormal cells.

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Stand: 17.01.2020
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