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Evaluation of Three Novel Methods for Counting ...
60,70 € *
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Abnormal respiratory rate is a marker of serious illness, yet hospital based research shows that respiratory rate is under-reported when compared to others vital signs. Measuring respiratory rate frequently and communicating abnormalities in respiratory rate parameters, has the potential to reduce morbidity and mortality in hospitalized patients. This book discusses the work related to the reliability and validity of three novel methods for counting breaths by using a mobile phone application. A simple mobile phone application could be used as a powerful tool to effectively count and monitor respiratory rate.

Anbieter: Dodax AT
Stand: 17.01.2020
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Role of Syndecan-1 as a Diagnostic marker in Ab...
69,80 € *
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I have written this book during my three years of postgraduate medical education in pathology which got completed in 2016. This book is based on my M.D dissertation which deals with one of the most encountered gynecological problems in women. This was only possible under the guidance of my respected teachers and co-authors like Dr. Roobina Khan, Prof Veena Maheshwari and Prof Seema Hakim. I have shared my experience as a pathologist in diagnosing various etiologies of abnormal uterine bleeding in women as per latest FIGO PALM-COEIN classification and its impact on their quality of life. Moreover, in developing countries like India, a large percentage of women is reluctant to seek medical advice and treatment. Hence this book intends to create awareness among womenfolk for seeking health care services so as to lead a healthy and productive life. Through this platform, I have tried to keep you all abreast with the latest techniques like immunohistochemistry in the diagnosis of various neoplastic and non-neoplastic diseases of the endometrium. Just give a read and get acquainted with the latest techniques in modern medicine for early diagnosis and proper management of the patients.

Anbieter: Dodax AT
Stand: 17.01.2020
Zum Angebot
Role of Syndecan-1 as a Diagnostic marker in Ab...
67,90 € *
ggf. zzgl. Versand

I have written this book during my three years of postgraduate medical education in pathology which got completed in 2016. This book is based on my M.D dissertation which deals with one of the most encountered gynecological problems in women. This was only possible under the guidance of my respected teachers and co-authors like Dr. Roobina Khan, Prof Veena Maheshwari and Prof Seema Hakim. I have shared my experience as a pathologist in diagnosing various etiologies of abnormal uterine bleeding in women as per latest FIGO PALM-COEIN classification and its impact on their quality of life. Moreover, in developing countries like India, a large percentage of women is reluctant to seek medical advice and treatment. Hence this book intends to create awareness among womenfolk for seeking health care services so as to lead a healthy and productive life. Through this platform, I have tried to keep you all abreast with the latest techniques like immunohistochemistry in the diagnosis of various neoplastic and non-neoplastic diseases of the endometrium. Just give a read and get acquainted with the latest techniques in modern medicine for early diagnosis and proper management of the patients.

Anbieter: Dodax
Stand: 17.01.2020
Zum Angebot
Epigenetics in cancer
79,90 € *
ggf. zzgl. Versand

Aberrant DNA methylation of CpG islands (CGIs) is a common alteration during malignant transformation that leads to the abnormal silencing of tumor suppressor genes and plays a role in disease initiation and progression. The main focus of the present work is the implementation of methodologies to identify epigenetic marker genes that can be used for the diagnosis as well as for the targeted treatment of tumors. The newly developed methyl CpG immunoprecipitation (MCIp) technique allows for the unbiased genome-wide profiling of CpG methylation in DNA samples where quantity is limited. The comprehensive analysis identified a large array of CGIs that are previously unrecognized targets of hypermethylation in acute myeloid leukemia (AML). Furthermore, the molecular mechanisms controlling the methylation status of CpG islands in normal and malignant cells were analyzed and factors were identified that are responsible for maintaining or establishing methylated states of CGIs in health and disease as well as for de novo methylation in cancer.

Anbieter: Dodax
Stand: 17.01.2020
Zum Angebot
Epigenetics in cancer
82,20 € *
ggf. zzgl. Versand

Aberrant DNA methylation of CpG islands (CGIs) is a common alteration during malignant transformation that leads to the abnormal silencing of tumor suppressor genes and plays a role in disease initiation and progression. The main focus of the present work is the implementation of methodologies to identify epigenetic marker genes that can be used for the diagnosis as well as for the targeted treatment of tumors. The newly developed methyl CpG immunoprecipitation (MCIp) technique allows for the unbiased genome-wide profiling of CpG methylation in DNA samples where quantity is limited. The comprehensive analysis identified a large array of CGIs that are previously unrecognized targets of hypermethylation in acute myeloid leukemia (AML). Furthermore, the molecular mechanisms controlling the methylation status of CpG islands in normal and malignant cells were analyzed and factors were identified that are responsible for maintaining or establishing methylated states of CGIs in health and disease as well as for de novo methylation in cancer.

Anbieter: Dodax AT
Stand: 17.01.2020
Zum Angebot
Periodontal Diagnostic Markers
68,00 € *
ggf. zzgl. Versand

Periodontitis is defined as an inflammatory disease of the supporting tissues of the teeth caused by specific microorganisms, resulting in progressive destruction of the periodontal ligament and alveolar bone with pocket formation, recession, or both . Diagnostic Marker can be defined as any biochemical compound such as antigen, antibody, abnormal enzyme, or hormone that is sufficiently altered in a disease to serve as an aid in diagnosis or in predicting susceptibility to the disease. Their findings serve as a basis for treatment planning and provide essential data during periodontal maintenance and disease-monitoring phases of treatment. Thus, we can say that biomarkers, whether produced by normal healthy individuals or by individuals affected by specific systemic diseases, are tell-tale molecules that provides pertinent information for differential diagnosis, localization of disease and severity of infection. Therefore, in this particular literature review, we aim to evaluate the potential diagnostic utility of various biological markers present in oral fluids, such as saliva and GCF and its potential application for the early diagnosis and treatment of periodontal diseases.

Anbieter: Dodax
Stand: 17.01.2020
Zum Angebot
Intracellular ion channel 1 between neurogenesi...
67,90 € *
ggf. zzgl. Versand

The cell cycle hypothesis for neurodegenerative diseases suggests a link between "cell cycle-like reactivation" and neuronal death, mainly in Alzheimer disease (AD), one of the most common neurodegenerative diseases for which an efficient treatment is yet to be identified. The insult represented by A deposits, a typical hallmark of AD, could force the neuron to re-enter the cell cycle. However, a highly differentiated cell unable to successfully accomplish a task normally attributable to immature cells, would end up in neuronal death. Considering neurodegeneration as a result of the abnormal activation in mature cells of a pathway that is typical of immature cells, the results shown in this book propose CLIC1 as part of this pathway, physiological and successful in immature cells, contributing to mantain growth cone morphology and sustaining axon outgrowth modulated by cAMP via PKA, but leading to cell death in mature neurons. Increased CLIC1 expression in the gangliar layer in AD mouse models before cognitive symptoms, proposes it as an early marker of AD. This study suggests a double role of CLIC1, in retinal ganglion cells physiology and pathology.

Anbieter: Dodax
Stand: 17.01.2020
Zum Angebot
Periodontal Diagnostic Markers
70,00 € *
ggf. zzgl. Versand

Periodontitis is defined as an inflammatory disease of the supporting tissues of the teeth caused by specific microorganisms, resulting in progressive destruction of the periodontal ligament and alveolar bone with pocket formation, recession, or both . Diagnostic Marker can be defined as any biochemical compound such as antigen, antibody, abnormal enzyme, or hormone that is sufficiently altered in a disease to serve as an aid in diagnosis or in predicting susceptibility to the disease. Their findings serve as a basis for treatment planning and provide essential data during periodontal maintenance and disease-monitoring phases of treatment. Thus, we can say that biomarkers, whether produced by normal healthy individuals or by individuals affected by specific systemic diseases, are tell-tale molecules that provides pertinent information for differential diagnosis, localization of disease and severity of infection. Therefore, in this particular literature review, we aim to evaluate the potential diagnostic utility of various biological markers present in oral fluids, such as saliva and GCF and its potential application for the early diagnosis and treatment of periodontal diseases.

Anbieter: Dodax AT
Stand: 17.01.2020
Zum Angebot
Intracellular ion channel 1 between neurogenesi...
69,80 € *
ggf. zzgl. Versand

The cell cycle hypothesis for neurodegenerative diseases suggests a link between "cell cycle-like reactivation" and neuronal death, mainly in Alzheimer disease (AD), one of the most common neurodegenerative diseases for which an efficient treatment is yet to be identified. The insult represented by A deposits, a typical hallmark of AD, could force the neuron to re-enter the cell cycle. However, a highly differentiated cell unable to successfully accomplish a task normally attributable to immature cells, would end up in neuronal death. Considering neurodegeneration as a result of the abnormal activation in mature cells of a pathway that is typical of immature cells, the results shown in this book propose CLIC1 as part of this pathway, physiological and successful in immature cells, contributing to mantain growth cone morphology and sustaining axon outgrowth modulated by cAMP via PKA, but leading to cell death in mature neurons. Increased CLIC1 expression in the gangliar layer in AD mouse models before cognitive symptoms, proposes it as an early marker of AD. This study suggests a double role of CLIC1, in retinal ganglion cells physiology and pathology.

Anbieter: Dodax AT
Stand: 17.01.2020
Zum Angebot